Here is a little experiment to demonstrate various options in macro photography. I used a Minolta Celtic 50/3.5 macro lens. 1. In this shot I focused on the centre/nearest part of the seed-head with the lens wide open @ f3.5. You see that the perimeter of the seed-head is quite soft. 2. This shot is taken as above but I changed the focus to the perimeter of the seed-head. Now the centre is soft but the perimeter is sharp. This is my preference between the two. 3. With this last shot I re focused on the centre/near & stopped the lens down to f12 to increase the depth of field so as to have most of the subject in focus. This has the effect of having the background becoming distracting. I am interested in the preference of others with these options.