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Overread said:The core operation of a DSLR of any level is identical - aperture, shutter speed and ISO are your variables that control exposure and that never changes. So you can certainly start at any level you want, the only real limit there is your budget and how much you can afford to invest - many start off at the earlier stages because they simply can't afford or justify going higher.
The only things you'll miss are maybe 5 or so auto modes like macro, landscape, action, portrait, no flash - otherwise the modes will be the same. Further if you're a keen photographer you'd fast never use those few auto modes anyway.
The higher level cameras will have more additional bells and whistles attached to them and cameras like the 5DMIII will have more customisable options. That said you don't have to jump in the deep end and learn them all to get good results.
That said what is your overall budget and what are you hoping to shoot with your camera? The 5DMIII is in all ways superior to the 6D - however sometimes you might find that investing the price difference into lenses and/or lighting gear might well give you far more gain than a higher end camera body. Some idea of your intent really helps for giving advice on how to approach things.
Bottom line...I'd start simple. Start with a good entry level camera like a Rebel T3i (great price at B&H right now B&H Shopping Cart | B&H Photo Video ) and learn the basics first. The key is to outgrow the capabilities of the camera...not buy everything in sight and get overwhelmed trying to use it.
One more thought..."full frame" is overrated in my book. There's nothing that says full frame cameras take better pictures than crop bodies. It's all about the photographer, not the box with glass on the front.
Dao said:If you are not going after the on-camera flash, auto modes that available only in the lower end cameras and most important cost is not a factor, I will say go with 5DIII.