It won't be as convenient to meter stopped-down; generally you would have to compose and focus with the aperture wide-open, before stopping down to meter. Or as Mike says you could just use a handheld meter. Either way the quality of the images won't suffer unless the lens is poor. I tried several old M42 lenses on my dSLR; some were not very good so obviously there was no point using them over a modern zoom, but I used a 50mm f/1.4 before I replaced it with an autofocus one; it hasn't got less sharp over the years and I had some good results with it. Also I still use an old 85mm f/2 with an adapter; yes it's not all that convenient but it costs a lot less than an equivalent modern lens and performs very well. Some people will say that CAD/CAM and various technologies make today's lenses much better... personally I think that at least when it comes to fairly basic primes, a good lens is a good lens. So if your lenses really are good then it could be worth it, but obviously it won't be as convenient as using a modern autofocus lens with a modern autofocus camera. Apart from anything else, most viewfinders and focusing screens now are designed to aid auto rather than manual focus.