I have a Mamiya 7. I'm mostly a large format guy but it is a stellar camera. Lenses are amazing, sharp like Leica lenses.
Three things. The first answer is yes. The lens is much longer, and more telephoto and it needs a faster shutter speed to compensate for hand-heldedness.
The second is that if you don't want to use a tripod... you can always try a monopod. It's only half as good, but will help nonetheless. I have a cheap aluminum one that weighs almost nothing (and costs almost nothing as well). It' only a stick with a screw in it, after all. Some are cool, they auto-extend and if I shot with one all the time I would get one of those. But my aluminum stick does the job...
The third thing is to get out there and go to a club with your camera, or any other similar venue, waste a few rolls of film and try it out... There's no substitute for experience. There are plenty of places open at night and when you are shooting you won't worry if you are doing it all for naught.
Lenny
EigerStudios