....and the light color at the location of the card is not always pleasant for the skin tone. That's the issue. LOL
I actually wondered about that. Depending on where you hold the card it could drastically effect the colors of the skin. The reflected light halfway between camera and subject might be different than the light falling ON the subject, depending on th source, etc. I suppose having them hold the card right by their face would be best? Haha
Put the card in the subject position under the key light. In practice, you usually have the subject hold the card up, or you walk over and take a picture of it.

Making a profile right from Lr is stupid simple. select the image of the card. Crop in on the card (not always necessary) and right click; select "export to Color Checker Passport (or the free x-rite ICC profile software if you didn't buy the Passport kit)". BAM. Profile created. Now you just select the color profile in the camera calibration field and done. At this point your colors should be spot on and ready for you to tune to taste.