Sure can.
It's called the Orton Effect.
Here's a bit of history of how it originally came to be:
The Orton Effect Explained
You can do this in any good PP software, Photoshop, GIMP, you name it... I use Capture NX since it fits my groove...
Each image is different, but here's what I basically do. I will explain it only in Capture NX terms since that's what I use, you can translate it to PP on your own.
I open up the RAW files, set the levels and curves so that everything looks good (as one normally would). I then take a look at the areas I want to hypersaturate and put a control point on them, and bump them up a bit. I put control points on any areas that I want lighter or darker, and I desaturate rocks to nearly gray. The reason I use Capture NX is that this whole process would take FOREVER in photoshop to get it to the level I am doing it at, with tons of layers and masks. In Capture NX, you simply click on what you want, move the slider and poof, it's done.
The last step in the process is sharpening (in this series, you don't sharpen at the end). I generally start with settings of 30, 2 and 4 in NX's USM.
Once I get my picture "ready", I save a version (NX 2 has versions built in, I haven't upgraded yet). I close the picture, and reopen it (a quick way of clearing the edits list).
Now, I apply the Orton Effect.
I adjust the levels and curves settings and put a 3 in the mid-point box...
I add gaussian blur with a ratios of 25, opacity of 100 (for starters... this is one you have to go back and adjust to taste later). I use the blending mode of multiply to give me lots of cool pixels to play with.
Next, I go back and do another levels and curves adjustments, but I change the setting to 2 instead of 3 in the center box and then changing the opacity mode to multiply.
After this is done, I look a the picture, and go back and change the radius of the blur as needed. You just have to look at is as you slide it and pick a spot. One of the neat things about Capture NX is how easy it is to paint blur... I know photoshop has this feature as well, but it works better in NX. If I need to I can use different levels of blur on different objects just by clicking on them and painting the blur to the right level.
Following all of this, if I like it I save a version.
Then, I take a look at what I have and generally go in and add a bunch of hypersaturated highlights. The purpose of this series is to create surreal landscapes to invoke dreamlike visions from the viewer, so when I go over the top with it I go WAY over the top.
Following these final adjustments, I make another version. This is my "final" full sized version.
I make another version, and then resize to 600x400 (or as appropriate) and look at it again. More than likely some changes will need to be made, often when the picture is shrunk it looks too dark, so I adjust the levels and curves again and save. I convert to JPEG and post it for you fine folks to see.