One-shot is the way to go. My theory is as follows. It isn't 100% scientific in terms of PS lexicon but I'm positive it's correct even if I can't explain it in a manner that's exactly technically precise:
-Unsharp mask increases contrast differentially by density in order to create sharper edges.
-If you sharpen a given area at 200% the edges become 200% sharper than the original.
Corrolary:
-If you sharpen a given area at 100%, the edges become 100% sharper than the original.
-If you sharpen
that image at 100% the edges become 100% sharper.
This functions in an exponential manner (though I don't believe it's ^2 (squared)), not a linear one. If you sharpen something at 50% and then sharpen again at 50%, it doesn't become 100% sharper than the original. Instead, it becomes 100%-200% sharper (likely closer to 200%, though I can't quantify precisely on theory and visual data alone).
The results can be seen in the following linked image, which is a 100% crop of a photo of mine, which is a scan of a Kodak Portra 160NC 645 negative. The results appear to be independent of the pixel radius. Sharpening twice at 50% percent always produces a more contrasty and artifacted image than sharpening once at 100%, so on and so forth.
Comparison