Did you do something funky with the first shot? The contrast of some of the elements in the pic look different from the others.
On my screen (which is calibrated, but...) it also looks like the color balance might be a bit out of whack... someone else mentioned the saturation.
I'm not familiar with your particular scanner... I have a Nikon CoolScan one lying around here somewhere. My experience was you generally wanted to be sure to set exactly what kind of film you were scanning as it could have a big effect on your results. (brand, make, as well as ISO, etc.)
On the noise stuff... some scanners have built-in noise and scratch reduction. My Nikon one does an AMAZING job with this, but you have to figure out how to turn it on and sometimes the software can be cantankerous.
BTW, there is a REALLY cheap application out there called Vuescan. It's a little clunky on the interface but it is WITHOUT EQUAL when dealing with negative scanners. The author also supports the app extremely well and when you buy it, you get a license with free upgrades in perpetuity. I found it had an unbelievable impact on my ability to scan negatives successfully.