I was browsing on Flickr this morning and came across this guy that does astrophotography...I am mind blown. This guy is incredible! Highly recommend you check out his album, its very inspiring.
The details he captures are just amazing. I think he uses a modified Canon 5D and a 500mm lens. I'm sure it must be paired with a high end telescope.
Astrophotography Flickr - Photo Sharing
Those are what I think of as classic astrophotography... the imaging requires a polar-aligned tracking mount. In each of the photographer's images, he indicates the camera, mount, and the number of "lights" (normal images), "darks" (same duration and settings as the "lights" but with the lens covered), "flats" (images taken of a plain, evenly illuminated field to detect lens or telescope image vignetting because these images will be aggressively "stretched" in post-processing and that will exaggerate the vignette effect -- the effect needs to be subtracted from the image before it is "stretched"), as well as "bias" frames (measures the amount of information read off the sensor even when no image was taken (shortest possible duration image just to force the sensor to power up and then read-out without capturing an image. Any levels above this "bias" level represent either signal (image data) or noise.
Narrow-field images typically require auto-guiding. Wide-field images do not necessarily need auto-guiding if the mount is reasonably well-aligned.
Often the imager will use a cooled CCD imaging camera (names like SBIG, Apogee, Finger Lakes, etc.) and these are monochrome cameras but a filter wheel is used to capture LRGB (luminance, red, green, & blue filters) and sometimes additional narrowband filters are used (Ha, Hb, O III, etc.).
But this imager (who does impressive work) is using an assortment of cameras including a 5D III, a 7D, and a modified Rebel T3 ("modified" means he did surgery on the camera and removed the IR filter. It's usually replaced with a better IR cut filter that allows more of the visible spectrum collected because a normal terrestrial filter cuts a significant amount of the Ha band.)
Single images will be extremely "noisy". The point of taking lots of images and stacking them is to knock back the noise. Sometimes (as is the case with his shot of M42) multiple sets of "lights" are shot at different exposures. M42 has a very bright core and faint outer nebulosity. The faint areas need long exposures to capture, but that blows out the core. Hence you can think of it like an HDR image (not the same technique though -- but the same idea.)
He doesn't say what software he uses to handle image integration. There are several. The best imager I know uses Photoshop (and really only Photoshop), but there are guys who use PixInsight, Nebulosity, MaxIm DL, and many others... there are even free programs like DeepSkyStacker.
The skill takes years to learn. I've managed to become fairly good at image acquisition, but I still struggle with image processing.