The best option is to consult the manual. However, if you don't have it...
the guide number should be 38 with the flash zoom set to 105mm (which is what you'd use with a 105mm lens on your camera). This guide number is for meters. So, if your subject is 5 meters away, you'd want to use an aperture number 38 / 5 = 7.6, so about f/8 if you're using a 105mm lens and ISO 100 film (or the ISO 100 setting on a digital). If you want to work with feet instead of meters, just multiply the guide number by 3.
This page may be of some help:
http://photonotes.org/cgi-bin/flash-specs.pl?flashType=canon380ex
It's not as scary as it sounds at first. Try it out, and look at your results. That's one great thing about digital... you can see the results right away and make adjustments.
Remember this: if the subject is too dark or too light, change your aperture to fix it (higher f-number to darken, lower the f-number to lighten). If the surroundings are too dark or too light, change your shutter speed (faster shutter speed to darken, longer shutter speed to lighten). Try it!
If you can, try moving the flash off the camera, or point it up at the ceiling. On-camera flash is generally a little bad for the image (deer in the headlights, red-eye, flat contrast, etc). If you bounce the flash at the ceiling, you'll have to adjust your exposure accordingly.
The best advice I can give you is to play with it. Experiment until you find a technique that works for you, then work with that.
Good luck!