ABSOLUTE worst case - boot Linux up on that sh!t and I guarantee it will work. (It's hard for me to call that a worst case scenario though, but some people are pretty attached to Windows.)
That last computer I bought shipped with 64 bit Windows 7 - I only used it long enough to open the DVD tray and reboot, but I know for a fact that dispcalGUI & ArgyllCMS will work with Linux Mint. I see no reason why it won't work in Windows though. Worst case (getting the Spyder2 to run on Windows 7), it will run 32 bit instead of 64 bit. Absolute worse case sticking with Windows, you might have to compile some code from source. That isn't as hard as it sounds.