I've never been to a shuttle launch before, so I don't have any direct experience with it.
It's going to be at night? To me, a long exposure (tripod, of course) with a wide enough lens to capture it all (in portrait orientation) would be pretty cool.
I would probably do that, and with another body with a longer lens try to get some closer, more detailed shots. That might be pretty hard to do if it's going to be dark though.
I searched "shuttle launch" in google images. Browse through that for ideas.
This one is what I had in mind with the long exposure. (Although I would have shot it in portrait orientation, but then again - I shoot most things in portrait orientation.)
edit
I had imagined it going more or less straight up. I don't think portrait would have worked for that one.