Room safes are a waste of space anyway, ever single person in the hotel knows the ‘special code’ to open them.
I just lock valuables in my case, I mean if they walk out with that then the hotel has a really serious problem!
My issue is more to do with hand luggage - my SonyA7 uses up all hand baggage allowance (along with headphones, all my spare chargeable batteries, watches (yeah I love watches so always got to take at least 3x on any trip).
This means all the lenses have to go in checkin baggage, along with film cameras, street camera (minus battery of course!) etc.
So I am always a little nervous at the luggage Carousell when I arrive at the destination!