Perhaps the worse thing one can do is sharpen very early in post processing. I would never apply sharpening in the raw dialog. In addition, the problem with sharpening in raw is that the sharpening is applied to the entire image, instead of just in the areas required. Sharpening where it is not needed damages the image, and can introduce digital artifacts.
Sharpening should be done as the last step because the amount and method of sharpening is a function of how the image will be used. This is why a completely mastered image must never be stored sharpened.
It is far better to archive mastered images with no sharpening.
So when does one sharpen? Just before you output the image. For prints sharpening is a function of the size of the print. For publishing on the web, sharpening is applied different still. Instead of applying sharpening to the entire image, it would be more beneficial to apply it only to those parts that require it, like the eyes, teeth, whatever is required per the composition. And to do it with the most benefit, apply it to a duplicate layer, then use a mask to paint in the effect only on the parts of the image that require it. This sounds complex, but with a little practice, one can do all this very fast and easy, and to stunning results.
If you archive a mastered image already sharpend, then you have applied an amount that cannot be undone, and will not necessarily be appropriate for all forms of output and all sizes of output for that image.
Moreover, it is best to archive images in the highest bit depth possible. You might be asking, why save a 8 or 12 bit image in 16 bits? Because when you apply sharpening and other tweeks later, a deeper bit depth will accommodate the rounding errors that come out of digital image math. Round errors mean combing, blocking and other bad digital artifacts.
As to bit depth, this has less effect on sharpening then pixel density. Although a lesser bit depth could give the perception of more "sharpness" because as one drops in bit depth, contrast often increases, and that increase in contrast is perceived as "sharper".