I've shot macro with APS-C cameras from Fuji,Canon,and Nikon, and have shot macro with FF cameras from Canon and Nikon. To me, using the camera's viewfinder, I like the full-frame cameras for their larger, better,crisper viewfinder image, compared with low-end cameras that were APS-C and which had rather poor viewfinder image quality, due to pentamirror design, or just that small, tunnel-like APS-C viewfinder that is a hallmark of APS-C amateur cameras. Lenses were "real" macro models, among them 55mm/3.5 manual focus,60mm/2.8 AF-D,90mm/2.8 AF-SP,100mm USM-IF/2.8,and 180mm/3.5 APO-HSM ED-IF from Sigma. Also used the Nikkor 300/4 AF-S with extension tube and/or a 1.4x converter. That said...many people find that Live View and the large,crisp, bright image it provides levels the playing field between APS-C and FX as far as being able to compose well, see well,and focus well.
A good example of what I mean is like say, the Fuji S2 Pro d-slr, or the Nikon D3200...low-end bodies, with a pentamirror viewfinder, and a somewhat 'economy' viewfinder system in total, as opposed to say the BEST APS-C viewfinder Nikon made, in the $5,000 D2x body, or the D500 body's extremely contrasty,bright, and crisp viewfinder: being able to literally SEE everything, super-clearly, is a major plus to me. The pentamirror bodies just do not HELP me, but rather, get in my way, when it comes to looking at and adjusting the image/composition/focus. And this is where Live View might be a big help.
I dunno...D500,D750...both are modern, similar MP counts...if you'd move to a 36-MP FX or a 45-MP FX, then it's be a different kettle of fish. I think one ought to use whatever one prefers to use.