I realize given all the possibilities that the answer is no, but hypothetically, all other things being equal, should the ISO be the last thing I adjust to allow the light in. Maybe a better way to ask, should ISO be the last thing I go to to get the right exposure for the shot?
The goal is to get the best photos. All other things are never equal, and to boot, you're asking for a practical answer about a hypothetical question? Uh...where to start.
Accept that not everything is equal. Ever. Photography, and the world, vary. A lot. Sometimes, ISO selection is a critical factor in success or failure. Late in the afternoon, as twilight comes, if you want to do stop-action photography, OR if you have a slow lens (say an f/5.6 max. aperture zoom), you will want to BEGIN WITH an elevated ISO level, and work from that starting point.
In low-light sports shooting scenarios, I will often START with the premise that ISO 1600 is **the best** place to begin, and will work on exposure with that as a given starting point. With new cameras, ISO 3,200, 6,400, and 12,800 are ALL actually pretty usable with the better, newer cameras, especially for smaller images and web use.
In bright-light situations where you are going to shoot fill-flash, I would begin with the LOWEST ISO your camera offers, since f/16 at the ISO in use is the "sunny 16" exposure, so with a camera having a 1/200 top flash synch speed, and a base ISO of 100, at the base ISO, the exposure for the sunlight will be 1/100 second at f/16, up to 1/200 second at f/11. If the camera offers a LOW setting, such as an equivalent to ISO 50, you might want to start with that ISO. (suffering only a slight loss in dynamic range, but no big deal).
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If you come right down to a "general idea", I would say under many situations, ISO 400 offers the best mix of ISO speed, shutter speed, depth of field, and FLEXIBILITY over exposures that are possible. It might have some loss of DR and color richness, but the newest sensors are still excellent, and again, the goal is to be able to make
the best pictures...not concerning yourself with a bunch of technical B.S. and arcane, esoteric crap that some people fixate on. A slight bit of noise or a slight loss of total DR or a slight loss of richness in color is better than a low-noise, low-ISO but a bunch of smeary, blurred images.