Sweet baby. I'm not sure what sort of shot you are going for, but if this was a thought-out session as opposed to a spur of the moment thing I would suggest the following:
~Try to get Baby looking at you or at least in your general direction. Shots with wide-open eyes seem to be most attractive overall, but you may have to wait around a while to catch that - try blowing lightly on his face to see what happens.
~Focus on the eyes - always. Ideally you want them tack-sharp or as close to that as possible and catching the light (not in the shadows).
~Try in front of a bright picture window in the morning - if you can get that really bright indirect light on him, it will make a big difference in the clarity/quality of the shot.
~Dress him in either the plainest clothing possible (naked or white onesie for example) or consciously dress him in something that will suit the mood of the shot - block colors work well, for example.
~Keep everything else that might be distracting/clutter out of the shot - toys, etc.
~Focus on the eyes. I said it before, but it's that important!