I wish I could find Roger Cicala's tests of some high-quality primes using lens adapters...the center resolution figures were usually pretty good, but edges showed significant drops in resolution. How it happens is alignment errors...lenses need to be aligned extreeeeeeeemely precisely to perform well. This was his first article on adapter issues
LensRentals.com - There Is No Free Lunch, Episode 763: Lens Adapters
but there was a second test session with extensive comparisons of adapter/no adapter performance. I looked through the older articles, and web searched didn't give me the results I wanted, but basically, the issue is alignment problems. As he points out, the very high-performance Zeiss 35mm f/2 lenses tested showed for example, one side of the image exhibiting serious loss of quality due to the adapter being not aligned perfectly.
And notice that he said his testing showed that lens adapters are not precisely aligned and machine enough for **critical**, valid lens testing on their equipment: "
I won't bore you with another 20 graphs that look pretty much like these. We tried Leica to NEX and Leica to Micro 4/3 adapters, Canon to NEX, etc. We tried different lenses on one adapter. It didn't really matter. None of them would be acceptable for testing. Not one.
I'll point out that we carry only name-brand, fairly expensive adapters, not eBay $29 adapters. All of them are tested frequently and used frequently and none of the ones I tested today had any problems. Still, not one of them would be acceptable for testing, so I guess I'm going to have to order those expensive lens mounts after all."
But as he says in this article, video,
even 4k video puts low demands on lens performance! So that's a plus for the OP, who wants to adpat some older medium format film-era lenses to a digital camera.
A second way lens adapters can cause resolution issues is the thickness of the sensor stack (aka the protective glass array located right in front of ther sensor). As he shows, m4/3 cameras often have a VERY thick , 4mm thickness, piece of glass in front of the sensor, Canon has about a 2mm thick stack, and old film cameras have of course, no sensor, and use film. The issue here is basically, a miss-matching of the lens to the sensor and the glass stack it has in front of it. The issue here is really not the fault of the adapter, or multiple adapters, but just creating mismatches between a lens and a particular sensor. He has a couple articles on that
LensRentals.com - Sensor Stack Thickness: When Does It Matter?
LensRentals.com - The Glass in the Path: Sensor Stacks and Adapted Lenses
As far as the idea that multiple adapters, and four, or six, or eight mount-to-mount surfaces would create a situation where errors tended to "cancel one another out"...that's not logical in any way at all. At times, errors compound one another. Again, the issue really is one of alignment. And again...some made in China adapter that is
supposed to offer infinity focusing, but yet does NOT...means that the machining work is of extremely substandard quality. I don't mean glassless adapters that simply can not and will never achieve infinity focus, like say m42 to Nikon F, but adapters that should easily be able to achieve infinity focus...if an adapter is so poorly machined that the basic thickness of it is improper, then how much confidence would one have that the thing aligns precisely to the camera mount AND to the rear mount on the lens? And there are quite a few adapters that have this problem...