I will bump this, as I am sure KMH will see it soon and break it all down for you. I will give you a short version. 300ppi does not matter much unless someone is requiring that number (ie. a publisher). However, sharpening should be your very last step prior to printing.
It depends HOW it is referenced. In an image that is 4000 x 6000, expressed that way, it doesn't matter whether it is 1 or a gazillion PPI. since there IS no inch reference
However if expressed as a 16 x20 @ 300PPI . THEN It IS relevant
OR if your were taking your image resolution and finding the Print input resolution, it would be relevant 3000 x 4000 / 16 X 24 Print = 187.5 ppi which is above what Print labs require