What Keith^ said is right on the button AFAIC.
I would like to add a couple of before-you-print suggestions.
Many things that look pretty good on the screen or even at 8x10 look sort of ugly at 20" because, regardless of the pixel dimensions, the sharpness and color break down.
Shadow detail that looks decent on a monitor may disappear in a print because there is no transillumination.
Abrupt transitions from light to dark that look decent on a monitor may look pretty abrupt and unpleasant on a print.
so, since 8 x 10's are cheap, I suggest you take 8 x 10 sized and shaped snips out of the image that would correspond to that important area of a larger print and print that.
let's say this picture is 5000 pixels wide and I wanted to print this at 250 pixels per inch but I was concerned about the sharpness and the look of her face.
To save some money, I would clip out a section of the important part that was 2500 pixels wide (and 2000 pixels high) and print only that 8 x 10 area to see how it looked printed, if the detail and color still look good
There is nothing quite so aggravating as putting out good money to a custom printer and getting back a print that looked great on the screen or in a smaller print and now looks messy or fuzzy at a large size.