There is no one best setting. The only correct answer is - It depends.
The tricky part is getting the right shutter speed to ensure the car wheels are blurred.
To get the right shutter speed, you have to set the right lens aperture and image sensor ISO.
Consequently, you need to be pretty familiar with the exposure triad so you understand how the 3 relate to each other.
In general, the amount of light you have available will determine which ISO setting you use. With ISO the goal is to always use the lowest native ISO setting you can. that minimizes image noise.
Once ISO is set, you adjust the lens aperture and shutter speed. If you need less shutter speed (likely on a bright day) you must make the lens aperture smaller so it lets in less light. If you need more shutter speed you must open the lens aperture. However, there are physical limits to how small and how large the lens aperture can be made. So, it depends what camera and lens you are using.
In bright daylight you may need to add a dark filter to the front of the lens to help reduce the amount of light the lens lets in.