So I was doing some indoor low light shooting with my 5DS R a few nights ago and I knew the photos would not be required to print at the size of a large scale poster. So, I shot on the MRAW setting to save some space and let my system run a little faster when editing (1600+ photos can be a lot). I was shooting at f2.8 ISO 2000 and a shutter speed of 200. What i noticed when in the edits is the noise was greatly reduced when compared to the full RAW files in the same settings. Lightroom and Photoshop had no issue working with the files either. Another side effect was an increase in buffer when doing long action shots.
I love the 5DS R, but it was getting really frustrating when not shooting in pure studio with flash to really get all the detail. Now that I have seen what happens with the MRAW I may find my self using that more often and only going to the full size when I know the prints will require such a file size. Just my two cents