As a general rule, most lenses have a "Sweet Spot", an aperture where they are the sharpest. A good "rule" for group photography, if you have more than one row, is to use an aperture no lower than 5.6 and focus on the middle row. A focus plane isn't from a starting point and then only things behind it. It's more of a point in space and then ahead and in back of that point will be in focus, more or less, depending on how low your aperture is. The best test is to take a row of bottles, set them up like you would your people in a photograph and then do some tests using different apertures. Make sense? And manual focus has nothing to do with why there not in focus. AF should work just fine as long as you set your focus and then recompose.