There **is a significant, noticeable and a very, real difference** between shooting with an APS-C or other smaller-sensor digital camera, and a 35mm-sized or 24mm x 36mm sensor camera( called FX by Nikon, or FF, AKA full-frame digital by many) as well as between a 35mm sensor size camera, and a medium-format rollfilm type camera, like say a 6x6 square camera like a Hasselblad. Mamiya, or Rollei,etc..
The simplest explanation is that the smaller the sensor or film size, the MORE depth of field there is at each picture "angle". Let's say we want to make a normal-lens picture--not an ultra-telephoto, tightly frames image, and not an ultra wide-angle panoramic image, just a normal picture. A point and shoot with a teeny-tiny sensor has almost infinite depth of field with its normal lens; an 8x10 view camera has very little depth of field with its normal lens; in between those extremes, there is MORE depth of field at each picture angle of view, as the sensor or film size gets smaller.
Here is one of the best articles I've seen on the issue. One that's accurate, and factual, unlike many pieces written about this issue.
Depth of Field and the Small-Sensor Digital Cameras - photo.net
SOME BULLET POINTS:
- For an equivalent field of view, the small-sensor camera has at least 1.6x MOREdepth of field than a full-frame camera would have - when the focus distance is significantly less then the hyperfocal distance (but the full-frame format need a lens with 1.6x the focal length to give the same view).
- Using the same lens on a small-sensor camera and a full-frame camera, the small-sensor image has 1.6x LESS depth of field than the full-frame image would have (but they would be different images since the field of view would be different)
- If you use the same lens on a small-sensor camera and a full-frame camera and crop the full-frame image to give the same view as the digital image, the depth of field is IDENTICAL
- If you use the same lens on a small-sensor camera and a full-frame camera, then shoot from different distances so that the view is the same, the small-sensor image will have 1.6x MORE DOF then the film image.
- Close to the hyperfocal distance, the small-sensor camera has a much more than 1.6x the DOF of a full-frame camera. The hyperfocal distance of the small-sensor camera is 1.6x less than that of a full-frame camera.