It's only f/5.6 at the long end, and the long end is the weaker end of the lens,optically. I don't shoot "nature" photos really, and if I did, it would be with a 300mm f/4 AF-S prime, or 300/2.8, and TC 1.4x if needed. "Nature" also encompasses macro and close-up work to many people...I don't really have an informed opinion on the 70-300 VR as a pseudo macro or close-range lens...my experience with it has been for portraiture, soccer in GOOD-wether daylight, and some travel/landscape shooting all on the D2x and D3x bodies. ANd a few frames on the D70. On the lower MP cameras, 12MP and UNDER, the lens is a solid performer. The D3x shows some of its weaknesses at the longer FL ranges. I have shot only a handful of floral close-ups with it, not enough to really give an opinion. This lens fills the portability/convenience/price/optical performance needs of its price and size range VERY admirably, for the kinds of things I use it for.