IS or VR works great when panning--and it works better than any tripod or monopod form smooth,beautiful panning results. IS or VR works splendidly in windy conditions, like when photographing along coastlines, estuary areas, or large,open rivers where windy conditions constantly buffet the photographer,and where even a tripod will not help much. IS or VR works great when you a re a bit out of breath, or your heart is pounding, like when hiking, or when that 10-point buck materializes through the fog and your heart starts to pound as an adrenalin surge rushes through your body; under both situations, a stabilized big telephoto on a monopod is good for 3 or four stops worth of steadiness. VR or IS works great when photographic static landscapes or scenic views with pokey,slow lenses like the 80-400 or 100-400 or 18-200 at the long end of their range.
VR or IS are unbeatable when photographing from moving,vibrating platforms like helicopters, aircraft, moving cars, fishing boats, ferry boats, etc.