do you use them all or do you prefer one over the other?I like Imagenomics, NoiseWare Pro, but also use Camera Raw/Lightroom (ACR 6).
It is better to not have noise in the original, because noise reduction will always reduce detail to some extent.
Which is why noise reduction is considered one side of a coin, On the other side of the coin is image sharpening.
Real World Image Sharpening with Adobe Photoshop, Camera Raw, and Lightroom (2nd Edition)