Besides, ouch, I think there is an interesting dichotomy between the attitude of the subject's appearance and that innocent smile. I like that a lot. It's a visual irony.
I'm not one of those people who say "Oh God, his eyes are not in it's perfect axis!". However, I think the subjects posture is off a bit. His chin is down as if his neck is extended toward the camera. This is the only thing I would fix.
-Nick