Ann he's not talking about dead pixels, he's talking about a dead sensor.
When I picked up my lens from a camera repair shot I saw a Canon 350D with a dead sensor. The owner did a 40min exposure. Not sure when in the process it died, it may even have failed during noise reduction afterwards. Either way it's a big risk and there's no easy number to stay away from. I have also seen a wonderful 45min startrail shot, noisy as heck but also done on a still working 350D.
I have done a 1 hour exposure on my D200 but the image was totally useless. Purple bleeding over the entire frame and the number of dead pixels were as high as several percent. There's quite a few threads current here where people are asking what the purple bleeding is after taking only a 15 minute exposure. Also long exposure NR sometimes totally fouls this up making the rest of the image green.
I assume you're trying to do star-trails? Try a stacking technique
http://www.tawbaware.com/imgstack.htm. The many short intermittent breaks during exposure will reduce heat (but sensor burnout would still probably be an issue so take care). The various frames also cause the sensor to reset eliminating the purple bleeding.