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I quite often use multiple brushes in LR, along with filters. Definatley slows it down but it's not unuseable for me, though it does delay the application. Sorry I couldn't be of more help but it sounds like backing up the catalogue then doing a fresh install may help
Where it becomes a problem is when you have a large number of images. The adjustments are cumulative in slowing down things. It will eventually get to the point that it's slow as molasses or it will lock up.