I have both of these. The X-PRO2 I've had for a while, but the X100F I recently added to my collection. Just for those who wanted to know the main differences. 1) X-PRO2 gives you the ability to change lenses. 2) X-PRO2 is faster to focus (due to the X100F lens being older, and fixed). 3) X100F is smaller and lighter 4) X100F appears WAY more customizable in terms of function buttons 5) X100F only has 1 SD card slot 6) The dials on the X100F are firmer 7) The eye diopter on the X-PRO2 is prone to knocks and causing issues (for me at least) 8) The MSC switch is in a much nicer place on the X100F 9) The viewfinder is nicer on the X-PRO2 So, there's 9 differences. I'm selling my X-PRO2 because the X100F meets all of my personal expectations (except the slightly slower focus time) - and brings me back to simple photography. I bought the X-PRO2 because I loved it. Another reason it's going is that I do not want to keep buying lenses. Just your average photographer with an opinion - thought somebody might find these differences worth while while making a choice on these cameras for the enthusiast.