If your camera is calibrated to 18% and you take a shot of an 18% gray card then the histogram is a flat line with a "spike" at the midpoint. If your camera is calibrated to 12% and you use an 18% gray card then the spike wont be in the middle (but it would be if you used a 12% card.)
I mostly use the gray card for white balance and if I really care about perfect metering, I use my incident meter ... not my gray card (and my own gray card is an 18% card even though my camera is calibrated to 12%). But if you DO use a gray card, and you use an 18% gray card with a 12% calibrated camera, just know that the histogram spike will be a little to the left of center.