Focusing with wide-aperture lenses at close focusing distances has been a problem for decades. There can be many factors at play. Karel Donk has a MAJOR hard-on for Canon and their many problems and issues.
And focusing on any other focus point than the center is weak at best in low light on the 5d2.
YES...and on the original 5D...same issue...it basically has NO peripheral AF points...the 5D and 5D-II used the AF system from the old EOS 20D, WHICH MEANT that the AF points were all quite centrally-located, in a tight diamond shape (with some hidden "assist" points added to the 5D Mark II body, but still, all of the AF points were within the tiny, centrally-located diamond shape in the middle portion of a 24x36mm field...).
A crop-body AF system SLAPPED INTO a full-frame camera....Canon 5tD CLassic and Canon 5D Mark II. The new 5D-III has got a SEXY, powerful, all-new AF and metering system!!! it's a humdinger of a camera!
Focus-and-recompose does NOT WORK as reliably as using a peripheral AF point on many fast lenses, used at close distances, and ESPECIALLY on cameras with weaker AF SYSTEMS, like the 5D and 5D Mark II cameras had. Add an ultra-speed lens like a 50/1.2-L or 85/1.2-L, and then add in moving subjects, poor light,m and widely varying degrees of user experience and skill...yeah, it's a lot like
newbies complaining that ,"It's hard to reach the summit of Mt. Everest."
I am most decidedly
not implying that the OP is a newbie, but the world wide web is filled with people carping about longstanding problems that some people have when using high-end, exotic equipment on pedestrian cameras under demanding conditions and withgout absolutely impeccable technique and adequate practice and preparation.
Uh, YEAH--
it IS difficult!!!!! "Doah!"