I have a very strong feeling that many Nikon users are going to consider these 2 cameras when they plan on buying their new camera. Why do I think so ? First because they are close in pricing and because of the insane ISO the D500 is rated at. Do I think they are comparable ? Not at all, these are very different cameras and when you think about it they shouldn't be compared because of few obvious reasons 1.FX vs DX 2.General use camera vs Sports camera So first lets talk about the obvious and most important thing Low light Performance Since the camera isn't out yet I am going to go by logic assumptions deducted from the dry details we already know. Like everyone know the fact a camera can go to a certain ISO natively doesn't mean it will produce cleaner image, never the less this might teach us that compared to other cameras in its segment we can expect to see cleaner results. Is this camera an FX destroyer ? I doubt that, did Nikon find a way to magically compensate for the lack of the extra light FX sensors bring ? So I still see the D750 getting about a stop (more or less) of performance advantage. Auto Focus The D500 AF system no doubt will be better, how much better we are yet to see but no doubt better. How much will it make a difference to the average user ? Well considering the D750 AF system is already amazing I doubt it will make a huge difference, for general use while 159 AF is nice it is a bit of an over kill. And just for the record I would LOVE to have 159 AF points on my D750 but as I said it really isn't a big deal. Buffer ? Again for general use even the buffer I used to have on my D7100 was fine, 200 RAW is really a fantasy number that 99% of people even sports shooters will not need. The buffer on the D750 is more then enough with 14 shots for all general user needs and more. Button/Dial layout This is a matter of personal taste and getting used to, I am sure I would love the D500 just as much as the D750, this is not something that would be an important issue one way or another for general use. Touch screen Nice bonus, will it be something used a lot ? Dont know, again personal taste, to me as a pure stills user I dont see much important but for those who do lots of video this will be a welcome feature 4K Again depends if you do lots of video, if you do then this again is a very welcome feature on D500 10 FPS vs 6.5 FPS For general user 10 FPS ? Nice For sports shooter Awesome I think the D750 hits a good FPS rating for what non sport dedicated user will ever need. I am sure there are lots more comparisons I missed but here is my summery D500 is hands down (again according to dry details) best crop sensor camera in the world and if you are a wildlife/sports shooter who cant afford the D5 or want the crop factor of a sport DX camera then this is the camera for you, when it comes to pure AF/FPS/Buffer the D500 is the clear winner but this post is not about that, this post is about the 2 cameras for general use with emphasis on stills photography and I think for me the D750 seems like the clear winner. Will the D500 be a good general use camera ? Absolutely, it has all that you need but the question is if it isnt a waste of money, you are paying for current best AF system which you probably want but not really need, huge buffer you really dont need and only thing I am not sure about is how good it is in low light, wouldn't getting the D7200 for DX user be a better way to spend the money ? You are getting an amazing DX camera which currently cost almost half the D500, in the money you can get an f2.8 constant zoom lens which will give you much better results then a kit lens. If life was perfect and money wasn't an issue I would want the D500 as a second body but money is an issue and I dont think for general user the D500 is the best way to spend his/her money. I am sure many will buy the D500 for general use and kudos for that as I said I would drool to have it but I just cant see justifying it.