Uh-oh...now you're thinking!!! lol
EXACTLY, jowens...how many times have we seen the post that basically reads as follows: "I just bought a 35mm f/1.8 and took a bunch of family pics and a lot of them are blurry,"? Have there been more of those posts, or more of the, "I just bought a 50mm f/1.8 and took a bunch of family pics and a lot of them are blurry!" posts? My vote goes to slightly more 50mm wide-open garbage threads.
I often say that a sharp but noisy photo is far better than a perfectly-exposed, low-noise SMEAR. In the many years I've been involved in photo forums, I've long been an advocate for shooting at an ISO level that is one or even two f/stops ABOVE base ISO...simply because it gives the photographer more choices, more leeway, more 'cushion'. I seldom if ever want to shoot wide-open...I often want to shoot at f/4.5 or f/4.8 or f/5.6. With flash, I often want to pick up MORE ambient light in the background, so I recommend to people to do as I do when shooting indoor bounce-flash: START at ISO 400, and notch up to 500 or 640 or even 800 ISO if it is at all needed.
For bounce flash situations, a lot of popular flashes simply do not have the power to get the kind of shots you WANT to get when the camera is laboring away under the artificial ISO 100 limit. For flash event work, using ISO 400 or 500, it means the flash will recycle and be ready for the next shot much sooner, battery sets last longer, and people are not BLASTED with full-capacitor discharge flash dumps...but instead, just brief little 'winks' of flash.