Ironically I grew up using a similar styled product as the Wacom tablet, though more advanced because instead of a standard tablet pad, it was more like an architect's mouse pad. (yeah, how's that for crazy advanced technology in a home setting in the 80's!?!) It had built in tools for CAD software, such as shortcuts for drawing lines, circles, filling in hatch patterns, etc. so from age 6 to about 12, I used that...left handed. When I got my own computer, I somehow learned to adjust to a mouse, right handed. I still edit right handed, but I am considering going back to both a wacom styled set-up. Now I have to decide if I'm ready to re-learn editing left handed (I'm a lefty naturally, so if I use a pen styled mouse, I naturally am going to be a bit better with the left.)