Hyperfocal is probably best used if youwant the absolute maximum depth of field for a given picture. Say a sunset where you want the rocks just infront of the camera also in focus. In that case I would focus to a couple of metres infront of me and set the aperature very small, f22 or something. If you are after the sharpest possible picture, pick an aperature 2 or 3 stops from wide open, so f8 for an f4 lens, focus right on the subject, and try and keep the shutter speed high to eliminate all motion.