I use ETTL all the time (I also have a 5D III, 600EX-RT's and the ST-E3-RT transmitter.)
If the scene has it's own ambient light (in other words it's not a studio) then you meter and set the exposure for the ambient light -- the flash will perform as fill light or accent lighting. NOW... depending on what you want the light to do, you can use ETTL (with liberal use of the "flash exposure compensation" control) as needed. This relates to something called "flash contribution".
Flash contribution is the percentage of light in the scene being contributed by the flash as compared to the light be contrived by the available lighting. I find, for example, that if I'm shooting outdoors and I want the images to appear to be lit entirely by natural light (but not look as bad as natural light can look) then I need to use the flash to weaken shadows, etc. I'd like the flash to be perhaps around 2/3rd or 1 stop weaker than the available light. So I'll use ETTL... but I'll set the FEC to -1 or -2/3rds and check the look.
On the top of the camera, the ISO button also has a box with the lighting bolt +/- button. That's the flash exposure compensation control. Incidentally... you can ALSO change flash exposure compensation by using the menu on the flash, but you cannot do BOTH at the same time. In other words, if you fiddle with the flash menu to set FEC then the camera will be locked out of also applying FEC. If you prefer to use the camera (which is probably faster) then use the flash's menu to set the FEC to "0" (that allows the ability to use the on-camera menu to adjust FEC).
The bottom line on ETTL is not to just leave the FEC at 0 all the time (which may result in a flat look.)
If you put the flash in manual then everything turns to the world of the inverse-square law. You can look this up (and there are plenty of flash photography tutorials that address it) but the rule says that as light is farther from the subject, the light rays spread out based on a math formula that is easy to calculate. As the distance increases (or decreases) by a factor of the square root of 2 (and for rounding purposes just use 1.4) then the amount of light will be halved (or if getting closer by that factor it will be doubled).
It turns out each f-stop on your camera is ALSO based on the powers of the square root of 2. f/4, for example is the square root of 2 raised to the 4th power. f/5.6... that's raised the 5th power. f/8... that's the 6th power, etc. etc. This is because when you change the diameter of a circle (or in this case, the area of the aperture hole in the lens) by a factor of the square root of 2 then you increase (or decrease depending on which way you're going) the AREA of that circle by example double (or half).
The flash power level control when shooting manual based on the fractional power level you want to use. The values are 1/1 (full), 1/2, 1/4, 1/8, 1/16th, etc. Notice that each one cuts the power level by half of the previous power setting.
So essentially you are using aperture setting, flash power output, and physical distance of the flash (from the subject) to control how it exposes in camera. If you use a lighting modifier (e.g. suppose you're using a "shoot through" umbrella) then the modifier is going to eat some light and you'd have to figure out how much it eats.
When you're doing a controlled shoot, you can adjust as needed to get the results you want and you know that the three variables you adjust are going to be the flash output power, the distance from subject, and the f-stop on camera (notice, btw, that shutter speed is NOT one of the settings you change. That just needs to be set at or below flash sync speed and if you're trying to collect ambient light to add depth to the lighting then you want it below that speed anyway.)
But what about those situations where you are pressed to get the shots quickly and don't have time to fuss with the lighting? Since it's all based on math, it's all highly repeatable. You will also find that in these types of situations your photos fall into categories that are also repeatable. Suppose you have a 50mm focal length (standard focal length lens for a full-frame camera) and you are shooting a "half shot" (waist-up composition)... the DISTANCE at which you stand to get that composition will be pretty consistent. You'll find the f-stop needed at the flash output power and use it. For example, at a wedding if I'm going to shoot a couple slow-dancing on the dance floor and I wanted a closer-framing half-shot of the two of them, I KNEW that I'd be about 7' away from them and I'd set f/16 and take the shot (f/16 was for the lighting I used back in those days... not with the 600EX-RT). But if I wanted a "full length" shot, then I'd move back to 14' and shoot it at f/8. Since the distance necessary to get that same framing is repeatable, the flash power and/or f-stop needed is ALSO repeatable. You can nail the shots without having to worry about it but it does mean you anticipate what framing you plan to shoot next and just pre-adjust the camera as you approach the subject. With a zoom this is more complicated and you really have to think about the distance you plan to shoot and not the framing (since you can change the angle of view by changing the focal length when using a zoom lens.)