I am a big guy, and I have huge hands, and I wish my cameras were even smaller than my current gear. It depends on what you shoot, it's why I use Rangefinders normally. They're the size of a big P&S. I like shooting people, and if you point one of those mega-SLRs with some kind of monster lens with many bells and whistles at them, you'll never get the shot.
Not every car needs to be an Escalade or Excursion, not every camera needs to be a Canon 1D. The notion that your hands are SOOO huge that you need a battery grip is kinda unlikely.
Think about what you really want to shoot.
Personally, I really want to get back to using SLRs for some work, but I just can't get myself to buy a 1D - it's humongous. I hope the 5D follow-up will be as small as the current model, maybe even smaller. I really am interested in weather-sealing. I am waiting for the new Leica SLR as well, but I just don't think it will be what I need....
Anyway, to get back to my point: think about what you need. All the big brands make something that fits many needs - don't worry about the brand first, worry about what you're shooting.