Dao
No longer a newbie, moving up!
I have that lens although I have not use it for awhile and planning to sell it, but it is not a bad lens to have. @300mm is a little soft but I think it is not that bad unless your copy has issue.
EOS 40D with EF 70-300mm f3.5-5.6 IS USM at 300mm, 1/320, f/5.6, ISO 200 (hand held with IS enabled) POST and Sharpened with LR4 (You can see the St. Louis Gateway Arch from his eye)
So OP, you may want to just do some test shot with your setup and see. Take multiple shots with various aperture settings of a road sign from a distance during the day and see what you get.
EOS 40D with EF 70-300mm f3.5-5.6 IS USM at 300mm, 1/320, f/5.6, ISO 200 (hand held with IS enabled) POST and Sharpened with LR4 (You can see the St. Louis Gateway Arch from his eye)

So OP, you may want to just do some test shot with your setup and see. Take multiple shots with various aperture settings of a road sign from a distance during the day and see what you get.
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