Duplicate your background layer, and use the clone tool to smooth it out. Low opacty, feathered brush.
Lower the opacity of the layer when you are done to let some of the original texture back in. Makes it look less fake. Then if you want/need, duplicate the layer again, run a 6 pixel gaussian blur, and set the layer opacity to 50%. Mask off everything but the face, and then mask off the eybrows, eyes, and lips. This leaves the skin nicely blurred and soft. Adjust the layer opacity again as need. I usually will drop it down around 25-35%.